Preston Lab

Irish Centre for Vascular Biology

The Preston Lab is located at the Royal College of Surgeons in Ireland (RCSI) and is part of the Irish Centre for Vascular Biology and the School of Pharmacy and Biomolecular Sciences.

We are interested in how coagulation proteases in the blood communicate with cells. We are particularly interested in the protein C pathway, whose multiple biological roles provide opportunities to engineer new therapeutic agents for haematological and inflammatory disease. In addition, we study how inflammation affects immune cell-mediated hypercoagulability in different disease cohorts.

Our group aims to develop new therapeutic and diagnostic approaches for treatment of haematological and inflammatory disorders.

Funding Support

Science Foundation Ireland

SFI Frontiers for the Future Award

National Children's Research Centre

Project Grant Award

Health Research Board

Investigator-Led Project Award

Irish Research Council

Postgraduate Studentship


View All

Heterogeneity in the half-life of factor VIII concentrate in patients with hemophilia A is due to variability in the clearance of endogenous von Willebrand factor

Einas Elsheikh, Michelle Lavin, Lilian Antunes Heck, Niamh Larkin, Brendan Mullaney, Dearbhla Doherty, Megan Kennedy, Catriona Keenan, Thomas Guest, Brian O'Mahony, Judicael Fazavana, Padraic G Fallon, Roger J S Preston, John Gormley, Kevin Ryan, Niamh M O'Connell, Evelyn Singleton, Mary Byrne, Mark McGowan, Sheila Roche, Mairead Doyle, Maeve P Crowley, Susan I O'Shea, Birgit M Reipert, Jill M Johnsen, Steven W Pipe, Jorge Di Paola, Peter L Turecek, James S O'Donnell, iPATH study group, pmid:36775768, doi:10.1016/j.jtha.2023.01.013,