Preston Lab at RCSI

Publications

Heterogeneity in the half-life of factor VIII concentrate in patients with hemophilia A is due to variability in the clearance of endogenous von Willebrand factor

 Einas Elsheikh, Michelle Lavin, Lilian Antunes Heck, Niamh Larkin, Brendan Mullaney, Dearbhla Doherty, Megan Kennedy, Catriona Keenan, Thomas Guest, Brian O'Mahony, Judicael Fazavana, Padraic G Fallon, Roger J S Preston, John Gormley, Kevin Ryan, Niamh M O'Connell, Evelyn Singleton, Mary Byrne, Mark McGowan, Sheila Roche, Mairead Doyle, Maeve P Crowley, Susan I O'Shea, Birgit M Reipert, Jill M Johnsen, Steven W Pipe, Jorge Di Paola, Peter L Turecek, James S O'Donnell, iPATH study group, pmid:36775768, doi:10.1016/j.jtha.2023.01.013,

The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing

 Mariana P Cervantes-Silva, Richard G Carroll, Mieszko M Wilk, Diana Moreira, Cloe A Payet, James R O'Siorain, Shannon L Cox, Lauren E Fagan, Paula A Klavina, Yan He, Tabea Drewinski, Alan McGinley, Sharleen M Buel, George A Timmons, James O Early, Roger J S Preston, Jennifer M Hurley, David K Finlay, Ingmar Schoen, F Javier Sánchez-García, Kingston H G Mills, Annie M Curtis, pmid:36470865, pmc:PMC9722918, doi:10.1038/s41467-022-34897-z,

von Willebrand factor links primary hemostasis to innate immunity

 Clive Drakeford, Sonia Aguila, Fiona Roche, Karsten Hokamp, Judicael Fazavana, Mariana P Cervantes, Annie M Curtis, Heike C Hawerkamp, Sukhraj Pal Singh Dhami, Hugo Charles-Messance, Emer E Hackett, Alain Chion, Soracha Ward, Azaz Ahmad, Ingmar Schoen, Eamon Breen, Joe Keane, Ross Murphy, Roger J S Preston, Jamie M O'Sullivan, Frederick J Sheedy, Padraic Fallon, James S O'Donnell, pmid:36329021, pmc:PMC9633696, doi:10.1038/s41467-022-33796-7,

Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction

 Helen Fogarty, Soracha E Ward, Liam Townsend, Ellie Karampini, Stephanie Elliott, Niall Conlon, Jean Dunne, Rachel Kiersey, Aifric Naughton, Mary Gardiner, Mary Byrne, Colm Bergin, Jamie M O'Sullivan, Ignacio Martin-Loeches, Parthiban Nadarajan, Ciaran Bannan, Patrick W Mallon, Gerard F Curley, Roger J S Preston, Aisling M Rehill, Ross I Baker, Cliona Ni Cheallaigh, James S O'Donnell, Irish COVID-19 Vasculopathy Study (iCVS) Investigators, pmid:35875995, pmc:PMC9349977, doi:10.1111/jth.15830,

The protein C pathways

 Gemma Leon, Aisling M Rehill, Roger J S Preston, pmid:35852855, doi:10.1097/MOH.0000000000000726,

Illustrated State-of-the-Art Capsules of the ISTH 2022 Congress

 Robert A Ariëns, Beverley J Hunt, Ejaife O Agbani, Josefin Ahnström, Robert Ahrends, Raza Alikhan, Alice Assinger, Zsuzsa Bagoly, Alessandra Balduini, Elena Barbon, Christopher D Barrett, Paul Batty, Jorge David Aivazoglou Carneiro, Wee Shian Chan, Moniek de Maat, Kerstin de Wit, Cécile Denis, Martin H Ellis, Renee Eslick, Hongxia Fu, Catherine P M Hayward, Benoit Ho-Tin-Noé, Frederikus A Klok, Riten Kumar, Karin Leiderman, Rustem I Litvinov, Nigel Mackman, Zoe McQuilten, Matthew D Neal, William A E Parker, Roger J S Preston, Julie Rayes, Alireza R Rezaie, Lara N Roberts, Bianca Rocca, Susan Shapiro, Deborah M Siegal, Lirlândia P Sousa, Katsue Suzuki-Inoue, Tahira Zafar, Jiaxi Zhou, pmid:35814801, pmc:PMC9257378, doi:10.1002/rth2.12747,

Identification of the factor XII contact activation site enables sensitive coagulation diagnostics

 Marco Heestermans, Clément Naudin, Reiner K Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä, Maike Frye, Carsten Deppermann, Giordano Pula, Piotr Kuta, Manuel A Friese, Mathias Gelderblom, Albert Sickmann, Roger J S Preston, Jerzy-Roch Nofer, Stefan Rose-John, Lynn M Butler, Ophira Salomon, Evi X Stavrou, Thomas Renné, pmid:34552086, pmc:PMC8458485, doi:10.1038/s41467-021-25888-7,