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Preston Lab

Irish Centre for Vascular Biology

The Preston Lab is located at the Royal College of Surgeons in Ireland (RCSI) and is part of the Irish Centre for Vascular Biology and the School of Pharmacy and Biomolecular Sciences.

We are interested in how coagulation proteases in the blood communicate with cells. We are particularly interested in the protein C pathway, whose multiple biological roles provide opportunities to engineer new therapeutic agents for haematological and inflammatory disease. In addition, we study how inflammation affects immune cell-mediated hypercoagulability in different disease cohorts.

News

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Awards at ISI 2022

Congratulations to Gemma and Aisling, who both won awards at the Irish Society for Immunology 2022 annual meeting in Maynooth this year. Gemma won 'Best Postdoc Oral Presentation Award' and Aisling won 'Best Poster' Prize.

Awards at HAI 2022

The lab attended the Haematology Association of Ireland 2022 annual meeting in Cork. Congratulations to Aisling, who presented her recent findings and was awarded 'Best Scientific Oral Presentation.

'Protein C Pathways' review published

A new review on 'The Protein C Pathways' written by Gemma and Aisling was published in 'Current Opinions in Haematology'!

Our group aims to develop new therapeutic and diagnostic approaches for treatment of haematological and inflammatory disorders.

Funding Support

Science Foundation Ireland

SFI Frontiers for the Future Award

National Children's Research Centre

Project Grant Award

Health Research Board

Investigator-Led Project Award

Irish Research Council

Postgraduate Studentship

Publications

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Dysregulated haemostasis in thrombo-inflammatory disease

Paula A Klavina, Gemma Leon, Annie M Curtis, Roger J S Preston, pmid:36524413, pmc:PMC9760580, doi:10.1042/CS20220208,

Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood

Sandra Konrath, Reiner K Mailer, Manu Beerens, Hanna Englert, Maike Frye, Piotr Kuta, Roger J S Preston, Coen Maas, Lynn M Butler, Mark Roest, Bas de Laat, Thomas Renné, pmid:36518684, pmc:PMC9742269, doi:10.3389/fcvm.2022.1008410,

The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing

Mariana P Cervantes-Silva, Richard G Carroll, Mieszko M Wilk, Diana Moreira, Cloe A Payet, James R O'Siorain, Shannon L Cox, Lauren E Fagan, Paula A Klavina, Yan He, Tabea Drewinski, Alan McGinley, Sharleen M Buel, George A Timmons, James O Early, Roger J S Preston, Jennifer M Hurley, David K Finlay, Ingmar Schoen, F Javier Sánchez-García, Kingston H G Mills, Annie M Curtis, pmid:36470865, pmc:PMC9722918, doi:10.1038/s41467-022-34897-z,

von Willebrand factor links primary hemostasis to innate immunity

Clive Drakeford, Sonia Aguila, Fiona Roche, Karsten Hokamp, Judicael Fazavana, Mariana P Cervantes, Annie M Curtis, Heike C Hawerkamp, Sukhraj Pal Singh Dhami, Hugo Charles-Messance, Emer E Hackett, Alain Chion, Soracha Ward, Azaz Ahmad, Ingmar Schoen, Eamon Breen, Joe Keane, Ross Murphy, Roger J S Preston, Jamie M O'Sullivan, Frederick J Sheedy, Padraic Fallon, James S O'Donnell, pmid:36329021, pmc:PMC9633696, doi:10.1038/s41467-022-33796-7,

Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction

Helen Fogarty, Soracha E Ward, Liam Townsend, Ellie Karampini, Stephanie Elliott, Niall Conlon, Jean Dunne, Rachel Kiersey, Aifric Naughton, Mary Gardiner, Mary Byrne, Colm Bergin, Jamie M O'Sullivan, Ignacio Martin-Loeches, Parthiban Nadarajan, Ciaran Bannan, Patrick W Mallon, Gerard F Curley, Roger J S Preston, Aisling M Rehill, Ross I Baker, Cliona Ni Cheallaigh, James S O'Donnell, Irish COVID-19 Vasculopathy Study (iCVS) Investigators, pmid:35875995, pmc:PMC9349977, doi:10.1111/jth.15830,

The protein C pathways

Gemma Leon, Aisling M Rehill, Roger J S Preston, pmid:35852855, doi:10.1097/MOH.0000000000000726,